The following clubs and activities are available to St. Charles College students:
- Athletic Council
- Art Club
- Concert Band
- Coding Club
- Choir
- Chess Club
- Computer Club
- Drama/Theatre Club
- Eucharistic Ministers
- Liturgy Committee
- Math Club
- Mission Society
- Peer Mediation
- Photography Club
- Robotics Club
- Student Council
- Travel Club
- Yearbook
- Yoga and Christian Meditation